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  • Model Organism Translatability

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For background on the challenges of Model Organism translatability:  http://ec.europa.eu/research/health/pdf/summary-report-25082010_en.pdf

 

Examples of biology non-translatable between human and mouse include:

  • Carcinogenic effects of Ppar-alpha agonists in mouse, but not human (PMID 18006136)
  • Human interleukin-8, a mediator of inflammation with no direct rodent equivalent
  • Human clathrin heavy chain isoform CHC22, not present in mouse, mediates glucose metabolism (PMID 19478182)