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Comment: Migrated to Confluence 5.3

This example demonstrates the use of a correlative relationship. Correlative relationships link abundances and biological processes when no causal relationship is known.

Code Block
SET Citation = {"PubMed", "J Pathol. 2005 May;206(1):28-38.", "15772985"}

SET Evidence = "Quantitative digital image analysis revealed
increased cytoplasmic expression of FGF-2 in bronchial epithelium
(0.35 +/- 0.03 vs 0.20 +/- 0.04, p < 0.008) and nuclear
localization in ASM (p < 0.0001) in COPD patients compared with
controls."

SET Tissue = "epithelium"

SET CellularLocation = "cytoplasm"

proteinAbundance(HGNC:FGF2) positiveCorrelation \
 pathology(MESHD:"Pulmonary Disease, Chronic Obstructive")

This statement expresses that an increase in cytoplasmic FGF2 protein positively correlates with an increase in the pathology Chronic Obstructive Pulmonary Disease. The subject and object terms of correlative statements are interchangeable. The negativeCorrelation relationship is used to represent inverse correlative relationships, i.e., a decrease in A is correlated with an increase in B.