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Comment: Migrated to Confluence 5.3

This example demonstrates use of a nested causal statement in which the object of a causal statement is itself a causal statement.

Code Block
SET Citation = {"PubMed", "Mol Cell Biol 2006 Aug 26(16) 6056-64.", "16880517"}
SET Species = "9606"

SET Evidence = "Consistently, the RNAi-mediated ablation of Claspin
 selectively abrogated ATR's ability to phosphorylate Chk1 but not
 other ATR targets."

proteinAbundance(HGNC:CLSPN) increases \ 
(kinaseActivity(proteinAbundance(HGNC:ATR)) directlyIncreases \
proteinAbundance((HGNC:CHEK1), proteinModification(P)))

short form:

Code Block
p(HGNC:CLSPN) -> (kin(p(HGNC:ATR)) => p((HGNC:CHEK1), mod(P)))

In the relationship described by the evidence text, CLSPN specifically increases the activity of ATR to phosphorylate the target protein CHEK1 and does not affect the kinase activity of ATR towards its other targets. The use of the nested statement allows the representation of the information that CLSPN increases the phosphorylation of CHEK1 via the kinase activity of ATR, without incorrectly indicating that CLSPN generally increases the kinase activity of ATR.