Many AOPs are described for specific cellular or tissue contexts. For improved integration of BEL with this feature of AOPs, tractable BEL solutions are needed to indicate these contexts at the node level. Node-level descriptors will immediately convey the specific context of a particular model.
Many AOPs describe key molecular events that occur in specific locations: whether a cell type, intracellular location, or tissue/organ. The location of the event is important information in an AOP and needs to be captured in a form that is useful and understandable, as well as tractable in BEL.