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Additional modification types can be requested as needed, or an external vocabulary can be used. Like other BEL namespace values, these modification types can be equivalenced to values in other vocabularies.

LabelSynonym
Acacetylation
ADPRibADP-ribosylation|ADP-rybosylation|adenosine diphosphoribosyl
Farnfarnesylation
Gergergeranylgeranylation
Glycoglycosylation
Hyhydroxylation
ISGISGylation|ISG15-protein conjugation
Memethylation
Me1monomethylation|mono-methylation
Me2dimethylation|di-methylation
Me3trimethylation|tri-methylation
Myrmyristoylation
Neddneddylation
NGlycoN-linked glycosylation
NONitrosylation
OGlycoO-linked glycosylation
Palmpalmitoylation
Phphosphorylation
Sulfsulfation|sulphation|sulfur addition|sulphur addition|sulfonation|sulphonation
SumoSUMOylation
Ububiquitination|ubiquitinylation|ubiquitylation
UbK48Lysine 48-linked polyubiquitination
UbK63Lysine 63-linked polyubiquitination
UbMonomonoubiquitination
UbPolypolyubiquitination
  • No labels

8 Comments

  1. New modification request: Sulfation

    Label - SO4 (to differentiate from just sulfur)

    Synonyms - sulfonation, sulfur addition, sulphation, sulphur addition

    Description - Sulfation in biochemistry is the enzyme-catalyzed addition of sulfate to another molecule.  The sulfate group is being added either via oxygen (O-sulfation) or nitrogen (N-sulfation).  See http://en.wikipedia.org/wiki/Sulfation.

    Type

    Species

    XREF - GO:0051923

     

     

    1. I think this is equivalent to MOD:00695 - SulfRes ("A protein modification that effectively substitutes a sulfonyl group for the hydrogen atom of a hydroxyl or sulfanyl group"). OK to use 'Sulf' as abbreviation to better match labels for other modification types?

  2. New modification requestion: S-nitrosylation

    Label - NO

    Synonyms - nitrosylation, protein S-nitrosylation

    Description -  S-nitrosylation, involves the covalent incorporation of a nitric oxide moiety into thiol groups, to form S-nitrosothiol (SNO).  See http://en.wikipedia.org/wiki/Nitrosylation.

    Type

    Species

    XREF - GO:0018119

  3. is S-nitrosylation limited to Cysteine? If so, should be equivalent to MOD:00235 (S-nitrosyl-L-cysteine)?

  4. It looks like S-nitrosylation is limited to Cysteine so equivalence is ... likely. 

    However, nitrosylation can also occur on the indol group of tryptophan and amine groups (Lysine or N-terminal).  See http://cardiovascres.oxfordjournals.org/content/62/1/43.full

    "Incorporation of NO moieties by covalent bonding to protein groups is chemically possible in the case of cysteine thiols, tryptophan indols and amines (lysine and N-terminal) [7–9], although S-nitrosylation, the formation of the S–NO bond by cysteine thiol nitrosylation, can be considered the most important, because of its higher reactivity, occurrence in physiological conditions and its influence on many protein functions."


     

  5. Thanks! Then 'NO' is a good label that should apply to thiol, indole, and amine groups.

  6. updated modification type table to include sulfation and nitrosylation in default BEL namespace.