These examples demonstrate the use of the
prognosticBiomarkerFor relationships to represent information about biomarkers in BEL Statements.
biomarkerFor relationship represents the known use of an abundance or process as a marker for a biological process or pathology.
These statements indicate that DES is a biomarker for the GO biological processes 'cardioblast differentiation' in heart and 'skeletal muscle tissue development' in skeletal muscle.
Because 'CardiovascularSystem' and 'Tissue' are different Annotation Types, the 'CardiovascularSystem' Annotation must be explicitly cleared so it does not apply to the second statement. Both Annotation Types and their allowed values must be defined in the BEL Document header.
prognosticBiomarkerFor relationship represents the use of an abundance or process as a biomarker for the future development of pathology in an individual disease case.
This statement indicates that abundance of the EGFR gene (gene copy number) is a prognostic biomarker that predicts the development of oral squamous cell carcinoma.